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Is Catheter Directed Thrombolysis Warranted? Greg Schwartzman,M.D., Jeff Geschwind,M.D., & George Hartnell, M.D. Johns Hopkins Hospital |
![]() Figs. 1. Magnified image from superior mesenteric arteriogram showing segmental narrowing of SMA branches consistent with a vasculitis. |
![]() Fig. 2.Ultrasound showed portal vein thrombus and dilatation to 21 mm. |
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A 22-year-old African-American male presented to an outside hospital two years previously complaining of malaise, fatigue, weight loss, abdominal pain, arthralgias, headache, and intermittent fevers. His past medical history was significant for uveitis and meningitis. On the basis of this history he was diagnosed as having Behcet's disease. |
![]() Fig.3. Abdominal CT showing multiple low attenuation areas consistent with abscesses. Fig.4.Direct portogram showing dilated and occluded portal vein with saccular dilatation of multiple intrahepatic portal branches. |
| Using ultrasound and fluoroscopic guidance, a 21-gauge needle was used to access the portal vein and contrast was injected. This showed an extensively expanded and obstructed portal venous system that was aneurysmal and saccular in appearance. Thrombus extended into the SMV and distal splenic vein. The proximal splenic and inferior mesenteric veins were patent. A Cragg-MacNamara infusion catheter was placed in the portal vein and SMV and r-TPA (Alteplase) infused overnight at 0.02 mg/kg/hr. Angiography the next day showed minimal clearing of thrombus but significant residual thrombus. R-TPA was continued at the same rate. Angiography later that day revealed no significant change. The infusion rate of r-TPA was increased to 0.04 mg/kg/hr but after another 10 hours there was no further improvement. Therefore an Angiojet device was deployed but only had the effect of causing thrombus to develop in the splenic vein and the IMV. Therefore r-TPA was continued for another 12 hours but final images after 72 hours of infusion there was no further clot lysis. The patient has been managed subsequently on heparin, coumadin, and three intravenous courses of antibiotics.
Questions: 1) Was catheter directed thrombolysis wise in this patient with Behcets disease? Given the propensity for venous thrombosis in Behcets disease, was catheter manipulation too risky? Related Cases: Case 397_05 -- Portal vein thrombosis |
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